Pharmacokinetics and metabolism in drug design pdf
File Name: pharmacokinetics and metabolism in drug design .zip
- Drug Metabolism
- Pharmacokinetics and Metabolism in Drug Design
- Role of pharmacokinetics and metabolism in drug discovery and development.
Drug metabolism input to the discovery process has been to date largely on an empirical case by case basis. Considerable advances have been made, such that basic rules can be applied to the behaviour of a compound in man based on physico-chemistry and structure.
Until now, the area of drug metabolism and pharmacokinetics has been lacking in texts written for the Medicinal Chemist. This outstanding book, aimed at postgraduate medicinal chemists and those working in industry, fills this gap in the literature. Written by medicinal chemists and ADMET scientists with a combined experience of around years, this aid to discovering drugs addresses the absorption, distribution, metabolism, excretion and toxicity ADMET issues associated with drugs.
The book starts by describing drug targets and their structural motifs before moving on to explain ADMET for the medicinal chemist. It is the functional groups which most profoundly influence the drug molecules of which they form a part. They characterise the pharmacology, are essential to the activity, and alter the ADMET characteristics of each drug. Their effects follow a pattern, thus allowing medicinal chemists to predict and overcome potential challenges.
For this reason, the Editors have taken the unique approach of dividing the remainder of the book into chapters which each focus on a different functional group.
They describe drugs containing the functional group under consideration, explain why the group is there, and outline its physicochemical properties before going on to detail the ADMET issues.
The chapters cross refer where similar matters are covered but individual chapters can be used in a stand alone manner. The book ends with a discussion of future targets and chemistry needs. Professor Dennis Smith has worked in the pharmaceutical industry for 32 years after gaining his Ph.
D from the University of Manchester. For the past 2 years he has been a Pfizer Academic Research Fellow working on a part-time basis. His research interests and publications span all aspects of Drug Discovery and Development particularly where drug metabolism knowledge can impact on the design of more efficacious and safer drugs.
He has authored over publications including two books. Jump to main content. Jump to site search. Journals Books Databases. Search Advanced. Current Journals. Archive Journals. All Journals. New Titles. Pick and Choose. Literature Updates. For Members. For Librarians. RSS Feeds. Chemistry World. Education in Chemistry. Open Access. Historical Collection.
Preliminary content Front Matter Dennis A. Log in to access for FREE. Preface Dennis A. Contents Dennis A. Alex and R. Ian Storer. Beaumont, S. Cole, K. Gibson and J. Buy chapter. Kalgutkar and J. Scott Daniels. Walker, R. Jones, A. Nedderman and P. Kalgutkar, Rhys Jones and Aarti Sawant. Scott Obach. Smith and David S. Subject Index Dennis A. Download Citation. About this book Until now, the area of drug metabolism and pharmacokinetics has been lacking in texts written for the Medicinal Chemist.
From the book series: Drug Discovery. Author information Professor Dennis Smith has worked in the pharmaceutical industry for 32 years after gaining his Ph.
Pharmacokinetics and Metabolism in Drug Design
Edited by D. Smith, H. Walker, R. Mannhold, H. Kubinyi, H. Folkers, H.
Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. Corpus ID: Role of pharmacokinetics and metabolism in drug discovery and development. Lin and A. Lin , A. Lu Published Biology, Medicine Pharmacological reviews.
Understanding PK properties is essential for drug development and precision medication. Existing challenges and perspectives on future directions are discussed, and may stimulate the development of new research models, technologies, and strategies towards the development of better drugs and improved clinical practice. Understanding of DMPK properties is essential for drug development and precision medication. In this article, we provided an overview of recent research on DMPK with focuses on the regulatory mechanisms of pharmacokinetics, drug—drug interaction, mathematical modeling, non-classical metabolism and so on. Existing challenges and perspectives on future directions are also discussed. Pharmacokinetics PK is defined as the quantitative study of drug absorption, distribution, metabolism, and excretion ADME — i.
Role of pharmacokinetics and metabolism in drug discovery and development.
It seems that you're in Germany. We have a dedicated site for Germany. Drug Metabolism and Pharmacokinetics Quick Guide is intended for broad readership of those interested in the discipline of drug metabolism and pharmacokinetics who work in drug discovery coming from the various disciplines, a background such as of medicinal chemistry, pharmacology, drug metabolism and pharmacokinetics, bioanalysis, clinical sciences, biochemistry, pharmaceutics or toxicology.