Insulin resistance and metabolic syndrome pdf

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insulin resistance and metabolic syndrome pdf

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Metabolic Syndrome: Time for Action

Metabolic syndrome is a collection of heart disease risk factors that increase your chance of developing heart disease, stroke , and diabetes. The condition is also known by other names including Syndrome X, insulin resistance syndrome, and dysmetabolic syndrome. According to a national health survey, more than 1 in 5 Americans has metabolic syndrome. The exact cause of metabolic syndrome is not known. Many features of the metabolic syndrome are associated with "insulin resistance.

The constellation of metabolic abnormalities tightly correlates with cardiovascular dysfunction, resulting in high morbidity and mortality rates Reaven a. An estimated million people had diabetes worldwide in , and this number is predicted to rise to million by , with a high economic cost for disease management Whiting et al. Table 1 Clinical criteria for the diagnosis of metabolic syndrome. However, patients with type 2 diabetes are non-insulin-dependent, in these patients intensive insulin therapy lowers blood glucose levels, but increases body weight and cardiovascular risk, as demonstrated in the Action to Control Cardiovascular Risk in Diabetes ACCORD trial Wilson Intensive insulin therapy does not provide much cardioprotective benefit in adults, and two-thirds of patients with type 2 diabetes die of heart failure.

Patient Information Handout. The constellation of dyslipidemia hypertriglyceridemia and low levels of high-density lipoprotein cholesterol , elevated blood pressure, impaired glucose tolerance, and central obesity is identified now as metabolic syndrome, also called syndrome X. Soon, metabolic syndrome will overtake cigarette smoking as the number one risk factor for heart disease among the U. Effective interventions include diet, exercise, and judicious use of pharmacologic agents to address specific risk factors. Weight loss significantly improves all aspects of metabolic syndrome. Increasing physical activity and decreasing caloric intake by reducing portion sizes will improve metabolic syndrome abnormalities, even in the absence of weight loss. Specific dietary changes that are appropriate for addressing different aspects of the syndrome include reducing saturated fat intake to lower insulin resistance, reducing sodium intake to lower blood pressure, and reducing high-glycemic—index carbohydrate intake to lower triglyceride levels.

The Global Epidemic of the Metabolic Syndrome

Articles in the December issue discuss various health issues affecting school-aged children, including acne, eczema and growth disorders. Volume 42, No. The metabolic syndrome MetSy is increasingly common in Australia. It is associated with the rise in obesity and lifestyle risk behaviours. It is also controversial — its value in predicting cardiovascular disease and diabetes risk and in guiding therapy has been challenged. This article aims to provide advice on the diagnosis of the MetSy and the principles for its prevention and management in the context of primary care, taking into consideration aetiological factors and the complexity of managing its constituent risk factors.


Increasing studies have found that the pathogenesis and progression of MetS are closely related to inflammation 12, and is usually called.


The Metabolic Syndrome:

Modern lifestyles play a major role in facilitating the derailment of normal biological functions of cells and metabolic processes. In particular, an unbalanced intake of nutrients, in combination with environmental factors, gives greater vulnerability to several diseases. Generally, multiple molecular mechanisms of insulin resistance IR have been described, and it is possible to attribute IR pathologic phenotype to a single specific cause, i. Recent data have shown that dysfunction of proteins involved either in insulin signal transduction or in the regulation of INSR expression provokes IR. In addition, a considerable amount of evidence about the pathogenesis of IR has suggested a strong relationship between nutrient excess and inflammatory molecules.

Metrics details. For many years, cardiovascular disease CVD has been the leading cause of death around the world.

The Global Epidemic of the Metabolic Syndrome

Metabolic syndrome is a clustering of at least three of the following five medical conditions: abdominal obesity , high blood pressure , high blood sugar , high serum triglycerides , and low serum high-density lipoprotein HDL. Metabolic syndrome is associated with the risk of developing cardiovascular disease and type 2 diabetes. Insulin resistance , metabolic syndrome, and prediabetes are closely related to one another and have overlapping aspects.

Adiponectin is an adipokine that is specifically and abundantly expressed in adipose tissue and directly sensitizes the body to insulin. Hypoadiponectinemia, caused by interactions of genetic factors such as SNPs in the Adiponectin gene and environmental factors causing obesity, appears to play an important causal role in insulin resistance, type 2 diabetes, and the metabolic syndrome, which are linked to obesity. The adiponectin receptors, AdipoR1 and AdipoR2, which mediate the antidiabetic metabolic actions of adiponectin, have been cloned and are downregulated in obesity-linked insulin resistance. Upregulation of adiponectin is a partial cause of the insulin-sensitizing and antidiabetic actions of thiazolidinediones.


Obesity and the metabolic syndrome (MS) are associated with impaired endothelium-dependent vasodilation (EDV). Insulin resistance, measured with formal.


Metabolic Syndrome

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