Structure and function of dna and rna pdf
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DNA structure and function
DNA deoxyribonucleic acid is the genomic material in cells that contains the genetic information used in the development and functioning of all known living organisms. DNA, along with RNA and proteins, is one of the three major macromolecules that are essential for life. Within the nucleus of eukaryotic cells, DNA is organized into structures called chromosomes. The complete set of chromosomes in a cell makes up its genome; the human genome has approximately 3 billion base pairs of DNA arranged into 46 chromosomes. DNA consists of two long polymers of simple units called nucleotides, with backbones made of sugars and phosphate groups joined by ester bonds. These two strands run in opposite directions to each other and are therefore anti-parallel. Attached to each sugar is one of four types of molecules called nucleobases bases.
Steve Minchin, Julia Lodge; Understanding biochemistry: structure and function of nucleic acids. Essays Biochem 16 October ; 63 4 : — Nucleic acids, deoxyribonucleic acid DNA and ribonucleic acid RNA , carry genetic information which is read in cells to make the RNA and proteins by which living things function. The well-known structure of the DNA double helix allows this information to be copied and passed on to the next generation. In this article we summarise the structure and function of nucleic acids. The article includes a historical perspective and summarises some of the early work which led to our understanding of this important molecule and how it functions; many of these pioneering scientists were awarded Nobel Prizes for their work. We explain the structure of the DNA molecule, how it is packaged into chromosomes and how it is replicated prior to cell division.
Nucleic acid , naturally occurring chemical compound that is capable of being broken down to yield phosphoric acid , sugars, and a mixture of organic bases purines and pyrimidines. Nucleic acids are the main information-carrying molecules of the cell , and, by directing the process of protein synthesis , they determine the inherited characteristics of every living thing. DNA is the master blueprint for life and constitutes the genetic material in all free-living organisms and most viruses. RNA is the genetic material of certain viruses, but it is also found in all living cells, where it plays an important role in certain processes such as the making of proteins. Nucleic acids are naturally occurring chemical compounds that serve as the primary information-carrying molecules in cells.
Role of RNA in Biology
RNA, in one form or another, touches nearly everything in a cell. RNA carries out a broad range of functions, from translating genetic information into the molecular machines and structures of the cell to regulating the activity of genes during development, cellular differentiation, and changing environments. RNA is a unique polymer. It can also bind specific proteins or small molecules, and, remarkably, RNA can catalyze chemical reactions, including joining amino acids to make proteins. Genes that are copied—"transcribed"—into the instructions for making individual proteins are often referred to as "coding genes.
DNA: Definition, Structure & Discovery
DNA is the genetic material found in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is found in the nucleus of eukaryotes and in the chloroplasts and mitochondria. In prokaryotes, the DNA is not enclosed in a membranous envelope, but rather free-floating within the cytoplasm. The entire genetic content of a cell is known as its genome and the study of genomes is genomics.
Components and structure of the nucleic acids. Polymerization occurs through the condensation of the phosphate on the 5' carbon and OH on the 3' carbon linkage. Eric Lander, Prof.
Alongside proteins , lipids and complex carbohydrates polysaccharides , nucleic acids are one of the four major types of macromolecules that are essential for all known forms of life. The two DNA strands are known as polynucleotides as they are composed of simpler monomeric units called nucleotides. The nucleotides are joined to one another in a chain by covalent bonds known as the phospho-diester linkage between the sugar of one nucleotide and the phosphate of the next, resulting in an alternating sugar-phosphate backbone.
This is a comparison of the differences between DNA versus RNA, including a quick summary and a detailed table of the differences.