Neutralization and antibody dependent enhancement of dengue viruses pdf
File Name: neutralization and antibody dependent enhancement of dengue viruses .zip
- Antibody-Dependent Enhancement of Viral Infections
- Antibody-Dependent Enhancement of Virus Infection and Disease
- Antibody-Dependent Enhancement: A Challenge for Developing a Safe Dengue Vaccine
The pathogenesis of dengue virus infection is attributed to complex interplay between virus, host genes and host immune response. Host factors such as antibody-dependent enhancement ADE , memory cross-reactive T cells, anti-DENV NS1 antibodies, autoimmunity as well as genetic factors are major determinants of disease susceptibility. Genomic variation of dengue virus and subgenomic flavivirus RNA sfRNA suppressing host immune response are viral determinants of disease severity.
Antibody-Dependent Enhancement of Viral Infections
Antibody-dependent enhancement ADE has been proposed as a mechanism to explain dengue hemorrhagic fever DHF in the course of a secondary dengue infection. Very recently, Dejnirattisai et al. The complexity of ADE in the context of a secondary dengue infection is discussed here. A rapid increase in dengue reports has been observed in the last three decades. Today, dengue infections are a serious cause of morbidity and mortality in most tropical and subtropical regions of the world: an estimated 50— million people are infected annually and over 2. These are transmitted to humans by Aedes mosquito bites, and Aedes aegypti is the main vector.
Antiviral antibodies constitute an important component of the host immune response against viral infections and serve to neutralize and reduce infectivity of the virus. However, these antibodies, intended to protect the host, may sometimes prove beneficial to the virus, by facilitating viral entry and replication in the target cell. The internalized immune complexes then modulate host immune response so as to enhance viral replication and aggravate disease severity. The possibility of induction of ADE remains a concern in the development and implementation of viral vaccines and immunotherapeutics. Antibody-dependent enhancement ADE of infection represents a paradoxical phenomenon in host—pathogen biology, in which, antibody, an important pillar of the host defense against invading pathogen, actually allows entry of the pathogen into host territory. This traitorous behavior of the antibody further serves to weaken the host defense system and thus generates an environment conducive for enhanced growth of the pathogen and consequently exacerbates disease in the host. This phenomenon has far-reaching implications for disease control and prevention, as therapeutic antibodies deployed to protect the host may aid the pathogen instead.
Dengue virus DENV is the cause of dengue fever. It is a mosquito -borne, single positive-stranded RNA virus of the family Flaviviridae ; genus Flavivirus. Dengue virus has increased dramatically within the last 20 years, becoming one of the worst mosquito-borne human pathogens with which tropical countries have to deal. Current estimates indicate that as many as million infections occur each year, and many dengue infections are increasingly understood to be asymptomatic or subclinical. Based on the analysis of the envelope protein, at least three genotypes 1 to 3 are known.
Antibody-Dependent Enhancement of Virus Infection and Disease
Metrics details. Antibodies are critical responses to protect the host from dengue virus DENV infection. Antibodies target DENV by two pathologic mechanisms: virus neutralization and infection enhancement. A total of pair serum samples from adult healthy volunteers were obtained during the dengue season in Ha Noi in for evaluation of neutralizing and infection-enhancing activity. Additionally, 20 serum samples from acute secondary DENV infection patients were also used as the patient group in this study. Out of residents, positive neutralizing antibodies N. A were found in
Request PDF | On Mar 29, , Tadahiro Sasaki and others published Dengue virus neutralization and antibody-dependent enhancement activities of and/or human monoclonal antibodies (MAbs) specific to viral surface.
Antibody-Dependent Enhancement: A Challenge for Developing a Safe Dengue Vaccine
If the address matches an existing account you will receive an email with instructions to reset your password. If the address matches an existing account you will receive an email with instructions to retrieve your username. In general, virus-specific antibodies are considered antiviral and play an important role in the control of virus infections in a number of ways. However, in some instances, the presence of specific antibodies can be beneficial to the virus.
The challenges associated with whole DENV-based vaccine strategies necessitate re-focusing our attention toward the designed dengue vaccine candidates, capable of inducing predominantly type-specific immune responses. The generation of type-specific antibodies to each of the four DENV serotypes by the designed vaccines could avoid the immune evasion mechanisms of DENVs. For the enhanced vaccine safety, all dengue vaccine candidates should be assessed for the extent of type-specific minimal ADE vs. The type-specific EDIII antibodies may be more directly related to protection from disease in the absence of ADE promoted by the cross-reactive antibodies.
На этот раз послышались длинные гудки. Фонтейн насчитал уже шесть гудков. Бринкерхофф и Мидж смотрели, как он нервно шагает по комнате, волоча за собой телефонный провод. Директор АНБ напоминал тигра на привязи. Лицо его все сильнее заливалось краской. - Невероятно! - воскликнул он и снова швырнул трубку. - Шифровалка вот-вот взорвется, а Стратмор не отвечает на звонки.
Сотрудник лаборатории систем безопасности не стал выдавать дежурного. - Я поменялся сменой с новым сотрудником. Согласился подежурить в этот уик-энд. Глаза Стратмора сузились. - Странно.
Офицер полиции этого не знает. - Не имеет понятия. Рассказ канадца показался ему полным абсурдом, и он подумал, что старик еще не отошел от шока или страдает слабоумием.