Metabolic syndrome and insulin resistance pdf
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- Insulin Resistance, the Metabolic Syndrome, and Complication Risk in Type 1 Diabetes
- Link between Metabolic Syndrome and Insulin Resistance
- Metabolic Syndrome
Nicholas A. Tritos, Christos S. AN exceedingly large number of studies have convincingly demonstrated that insulin resistance occurs in association with a variety of physiological and pathophysiological states, including obesity, noninsulin-dependent diabetes mellitus NIDDM , polycystic ovary syndrome PCOS , and the constellation of central obesity, hypertension, glucose intolerance, and hyperlipidemia known as metabolic syndrome or syndrome X 1 , 2 Table 1. In addition, a number of rare, albeit very interesting, syndromes characterized by extreme insulin resistance have been described over the past 20 yr 3 , 4. These syndromes are not only clinically important, but have also significantly contributed to our knowledge of the mechanisms of insulin action and resistance.
Insulin Resistance, the Metabolic Syndrome, and Complication Risk in Type 1 Diabetes
Adiponectin is an adipokine that is specifically and abundantly expressed in adipose tissue and directly sensitizes the body to insulin. Hypoadiponectinemia, caused by interactions of genetic factors such as SNPs in the Adiponectin gene and environmental factors causing obesity, appears to play an important causal role in insulin resistance, type 2 diabetes, and the metabolic syndrome, which are linked to obesity. The adiponectin receptors, AdipoR1 and AdipoR2, which mediate the antidiabetic metabolic actions of adiponectin, have been cloned and are downregulated in obesity-linked insulin resistance. Upregulation of adiponectin is a partial cause of the insulin-sensitizing and antidiabetic actions of thiazolidinediones. Therefore, adiponectin and adiponectin receptors represent potential versatile therapeutic targets to combat obesity-linked diseases characterized by insulin resistance. This Review describes the pathophysiology of adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. Go to JCI Insight.
JAMA Dermatol. Postadolescent patients were recruited only to negate the effects of physiologic insulin resistance that are seen at the time of puberty and adolescence. Twenty-five patients were included in each of the 4 individual severity groups according to the Global Acne Grading System and were age matched to male controls without acne. Prevalence of insulin resistance and metabolic syndrome did not differ significantly among the acne severity groups. This resistance may be a stage of prediabetes, and the patients may develop hyperinsulinemia or type 2 diabetes in the future. These patients should be followed up for a prolonged time to determine whether they develop conditions associated with insulin resistance.
To identify molecular defects contributing to metabolic dysregulation in DS in the undifferentiated state, we generated mesenchymal progenitor cells MPCs from induced pluripotent stem cells derived from a 4-week-old female with DS and a healthy newborn male control. However, alterations in receptor expression and pathway-specific defects in insulin signaling, even in undifferentiated cells, can alter cellular oxidative metabolism, potentially via transcriptional mechanisms. Type 2 diabetes T2D is a major public health problem worldwide. Intimately linked with the rise in diabetes prevalence is the burgeoning epidemic of obesity 1. Unfortunately, these alarming patterns are also increasingly observed in children and will likely translate into increases in cardiovascular and other health risks associated with insulin resistance and diabetes.
Link between Metabolic Syndrome and Insulin Resistance
Metabolic syndrome is a collection of heart disease risk factors that increase your chance of developing heart disease, stroke , and diabetes. The condition is also known by other names including Syndrome X, insulin resistance syndrome, and dysmetabolic syndrome. According to a national health survey, more than 1 in 5 Americans has metabolic syndrome. The exact cause of metabolic syndrome is not known. Many features of the metabolic syndrome are associated with "insulin resistance. A combination of genetic and lifestyle factors may result in insulin resistance.
PDF | Metabolic syndrome (MetS) is a leading public health and clinical challenge worldwide. MetS represents a group of interelated risk.
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Study record managers: refer to the Data Element Definitions if submitting registration or results information. The Metabolic Syndrome is a high prevalence disease worldwide. About a quarter of the adult population suffers the disease. Resveratrol is a substance found in many plants, including grapes, nuts and wine, but it's also found in Polygonum cuspidatum. There is evidence that resveratrol consumption has beneficial effects on glucose and lipids metabolism, blood pressure and body weight.